Citrus Aurantium Extract Powder

Model No.: CTA       

Product Name: Citrus Aurantium Extract Powder

Botanical Name: Citrus aurantium L.

Specification:

1. Synephrine 6%, 10%, 30%, 98% HPLC

2. Hesperidin 60%, 90%, 92%, 95%, 98% HPLC

3. Citrus Bioflavonoids 30%, 40%, 45%, 50%, 90%, 98% HPLC

4. Diosmin 90%, 92%, 95% HPLC, Diosmin:Hesperidin=9:1

5. Neohesperidin 95% HPLC

6. Hesperitin 95%, 98% HPLC

7. Naringenin 98% HPLC

8. Naringin 95%, 98% HPLC

9. Neohesperidin Dihydrochalcone (NHDC) 96%, 97% HPLC

10. Methyl Hesperidin 94%, 98% UV

11. Hesperidin Methyl Chalcone 98% UV

12. Naringin Dihydrochalcone 98% HPLC

 

Action:

1) It can obviously increase blood pressure, flow of coronary and renal artery as well as promoting urination.

2) lt is used to dispel bloating and a lump in the abdomen and phlegm, and to cureedema, constipation, gastroptosis, prolapse of uterus and rectocele.

3) It can strengthen the effectiveness of vitamin C, antiviral and antimicrobial, large doses can inhibit the influenza virus breeding.

4) It can help maintain normal permeability of blood vessels, improve capillary resistance, enhance the flexibility and tenacity, prevent and cure capillary hemorrhage or gums bleeding.

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1. Synephrine

Synephrine is an alkaloid (a pharmacologically active class of nitrogen-containing chemical compounds). Its chemical structure is similar to ephedrine, the primary active alkaloid in ephedra, aka ma-huang. There are only two chemical differences between ephedrine and synephrine: in synephrine one of the ring carbons is hydroxylated (a hydroxyl group {OH} replaces a hydrogen atom {H}), and a side chain methyl group (CH3; Me) is replaced by hydrogen.

 

Synephrine is found mainly in the medicinal products derived from bitter orange. Bitter orange also called Seville orange, is known botanically as Citrus Aurantium L. This ingredient appears to be present in slightly higher quantities in the unripe fruit than in the ripe fruit.

 

Assay: Synephrine 30% by HPLC

Appearance: Brown Powder

Particle Size: 100% through 80 Mesh

Loss on Drying: < 5.0%

Heavy Metals: < 20ppm

Arsenic(As): < 2ppm

Lead(Pb): < 2ppm

 

Total Plate Count: < 10,000cfu/G

Yeast & Mold: < 1,000cfu/G

E.Coli.: Negative

Salmonella: Negative

 

 

2. Hesperidin

Hesperidin is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits. Its aglycone form is called hesperetin. Hesperidin is believed to play a role in plant defense. It acts as an antioxidant according to in vitro studies. In human nutrition it contributes to the integrity of the blood vessels.

Various preliminary studies reveal novel pharmaceutical properties.

 

Hesperidin reduced cholesterol and blood pressure in rats. In a mouse study large doses of the glucoside hesperidin decreased bone density loss. Another animal study showed protective effects against sepsis. Hesperidin has anti-inflammatory effects. Hesperidin is also a sedative, possibly acting through opioid or adenosine receptors. Some in vitro results applied only to the aglucone form. Hesperidin also showed the ability to penetrate the blood brain barrier in an in vitro model.

 

Assay: Hesperidin 90% by HPLC

Appearance: Light Yellow Powder

Particle Size: 100% through 80 Mesh

Loss on Drying: < 5.0%

Heavy Metals: < 20ppm

Arsenic(As): < 2ppm

Lead(Pb): < 2ppm

 

Total Plate Count: < 10,000cfu/G

Yeast & Mold: < 1,000cfu/G

E.Coli.: Negative

Salmonella: Negative

 

 

3. Citrus Bioflavonoids

Citrus Bioflavonoids are bioflavonoids with obvious Biological Action extracted from citrus fruits. It has specific aromaticity and obvious pharmacological action. Clinical research testified that Citrus Bioflavonoids is not only pharmacology gene but also important nutrition gene. Typical sources for Bioflavonoids include the natural substances found in vegetables, fruits and grains. Bioflavonoids are required to be complemented as quick metabolism in human’s body.

 

The specific physiological activity of Citrus Bioflavonoids has obtained world recognition, and lots of healthy foods containing natural bioflavonoids as dietary supplements have appeared in current market, at the mean time, it has abroad application in cosmetics and pharmaceuticals.

 

Assay: Citrus Bioflavonoids 50% by HPLC

Appearance: Light Brown Powder

Particle Size: 100% through 80 Mesh

Loss on Drying: < 5.0%

Heavy Metals: < 20ppm

Arsenic(As): < 2ppm

Lead(Pb): < 2ppm

 

Total Plate Count: < 10,000cfu/G

Yeast & Mold: < 1,000cfu/G

E.Coli.: Negative

Salmonella: Negative

 

 

4. Diosmin

Diosmin is semisynthetic drug (modified hesperidin). It is an oral phlebotropic drug used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) and hemorrhoidal disease (HD), in acute or chronic hemorrhoids, in place of rubber-band ligation, in combination with fiber supplement, or as an adjuvant therapy to hemorrhoidectomy, in order to reduce secondary bleeding. To control internal symptoms of hemorrhoids (piles), it is used with hesperidin. Clinical studies have been inconclusive and no review articles on its use in vascular disease have been published.

 

Diosmin is currently a prescription medication in some European countries, and is sold as a nutritional supplement in the United States and the rest of Europe. Diosmin has been found to be effective in mitigating hyperglycemia in diabetic rats. It is also speculated that diosmin might have potential in the treatment of neurodegenerative diseases, such as Alzheimer's disease, and its anti-inflammatory and anti-apoptotic activity has been demonstrated in neuronal cells, in vitro.

 

Assay: Diosmin 90% by HPLC

Appearance: Greyish-yellow or Light Yellow Powder

Particle Size: 100% through 80 Mesh

Water: < 6.0%

Sulphated Ash: < 0.2%

Heavy Metals: < 20ppm

 

Total Plate Count: < 10,000cfu/G

Yeast & Mold: < 1,000cfu/G

E.Coli.: Negative

Salmonella: Negative

 

 

5. Neohesperidin

 Neohesperidin is mainly extract from Citrus aurantium, also known as Bitter Orange or Seville orange. It is a natural new nutrition sweetener widely existing in plants of dry orange peels, can be derived from extraction. Since the sweetness are 1300-1500 times than sugar, Neohesperidin are widely used in fruit juice, wine, beverage, bakery and pharmaceutical formulations sweeteners (Jiao deodorant), and particularly suitable for diabetic patients as food. In addition, it also can cure capillary fragility and protein permeability excessive. It is referred to as the maintenance of capillary permeability of vitamin or vitamin P, can be used as hypertension and myocardial infarction drugs.

 

Assay: Neohesperidin 95% by HPLC

Appearance: White Powder

Particle Size: 100% through 80 Mesh

Loss on Drying: < 5.0%

Heavy Metals: < 20ppm

Arsenic(As): < 2ppm

Lead(Pb): < 2ppm

 

Total Plate Count: < 10,000cfu/G

Yeast & Mold: < 1,000cfu/G

E.Coli.: Negative

Salmonella: Negative

 

 

 

6. Hesperitin

Hesperetin is one of the Citrus bioflavonoid. It is solid substance, light-brown crystalline powder, poorly soluble in water. Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.

 

Hesperetin is a cholesterol lowering flavanoid found in a number of citrus juices. It appears to reduce cholesteryl ester mass and inhibit apoB secretion by up to 80%. Hesperetin may have antioxidant, anti-inflammatory, anti-allergic, hypolipidemic,vasoprotective and anticarcinogenic actions.

 

Assay: Hesperitin 98% by HPLC

Appearance: White Powder

Particle Size: 100% through 80 Mesh

Loss on Drying: < 5.0%

Heavy Metals: < 20ppm

Arsenic(As): < 2ppm

Lead(Pb): < 2ppm

 

Total Plate Count: < 10,000cfu/G

Yeast & Mold: < 1,000cfu/G

E.Coli.: Negative

Salmonella: Negative

 

 

7. Naringenin

Naringenin is a compound that naturally occurs in grapefruit and other citrus fruits. Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulater.

 

This substance has also been shown to reduce oxidative damage to DNA in vitro. Scientists exposed cells to 80 micromoles of naringenin per liter, for 24 hours, and found that the amount of hydroxyl damage to the DNA was reduced by 24% in that very short period of time. Unfortunately, this bioflavonoid is difficult to absorb on oral ingestion. In the best case scenario, only 15% of ingested naringenin will get absorbed in the human gastrointestinal tract. A full glass of orange juice will supply about enough naringenin to achieve a concentration of about 0.5 micromoles per liter. There are speculations that, given more time at a lower concentration, it could have similar effects.

 

Assay: Naringenin 98% by HPLC

Appearance: White Powder

Particle Size: 100% through 80 Mesh

Loss on Drying: < 5.0%

Heavy Metals: < 20ppm

Arsenic(As): < 2ppm

Lead(Pb): < 2ppm

 

Total Plate Count: < 10,000cfu/G

Yeast & Mold: < 1,000cfu/G

E.Coli.: Negative

Salmonella: Negative

 

 

8. Naringin

Naringin belongs to a group of chemicals called bioflavonoids, which are colorful pigments found in plants. They were discovered by Nobel Prize-winning biochemist Albert Szent-Gyorgi, who labeled them "vitamin P" (although they were subsequently stripped of their vitamin status). Bioflavonoids belong to a larger group of phytochemicals called polyphenols. Key polyphenols include phenolic acids, flavonoids, stilbenes, and lignans. Flavonoids are the most abundant polyphenols in our diets.

 

Naringin is a flavonoid extracted from grapefruit and other citrus fruits (albeit in lower amounts). Naringin is a natural chemical compound known as a bioflavanoid found in grapefruit, giving it its bitter flavor. Hence, the food industry, however, uses naringin as a bitter in "tonic" beverages, bitter chocolate, ice cream, and ices.

This bioflavonoid has antioxidant and antifungal properties, and as such may help prevent cancer and atherosclerosis (hardening of arteries), as well as a number of other ailments, such as Herpes ,Diabetes, Alcoholism,  Heart failure, Chronic venous insufficiency, Bruising.

 

Assay: Naringin 98% by HPLC

Appearance: Light Yellow or White Powder

Particle Size: 100% through 80 Mesh

Loss on Drying: < 5.0%

Heavy Metals: < 20ppm

Arsenic(As): < 2ppm

Lead(Pb): < 2ppm

 

Total Plate Count: < 10,000cfu/G

Yeast & Mold: < 1,000cfu/G

E.Coli.: Negative

Salmonella: Negative

 

 

9. Neohesperidin Dihydrochalcone

Neohesperidin dihydrochalcone, sometimes abbreviated to neohesperidin DC or simply NHDC, is anartificial sweetener derived from citrus.

 

NHDC was discovered during the 1960s as part of a United States Department of Agriculture research program to find methods for minimizing the taste of bitter flavorants in citrus juices. Neohesperidinis one such bitter compound. When treated with potassium hydroxide or another strong base, and thencatalytically hydrogenated, it becomes NHDC, a compound roughly 1500-1800 times sweeter than sugar at threshold concentrations; around 340 times sweeter than sugar weight-for-weight. Its potency is naturally affected by such factors as the application in which it is used, and the pH of the product.

 

Like other highly sweet glycosides, such as glycyrrhizin and those found in stevia, NHDC's sweet taste has a slower onset than sugar's and lingers in the mouth for some time. Unlike aspartame, NHDC is stable to elevated temperatures and to acidic or basic conditions, and so can be used in applications that require a long shelf life. NHDC itself can stay food safe for up to five years when stored in optimal conditions.

 

Assay: Neohesperidin Dihydrochalcone 96% by HPLC

Appearance: White Powder

Particle Size: 100% through 80 Mesh

Loss on Drying: < 5.0%

Heavy Metals: < 20ppm

Arsenic(As): < 2ppm

Lead(Pb): < 2ppm

 

Total Plate Count: < 10,000cfu/G

Yeast & Mold: < 1,000cfu/G

E.Coli.: Negative

Salmonella: Negative

 

 

10. Methyl Hesperidin

Methyl hesperidin is a variety of water-soluble flavonoids&dihydro-methyl hesperidin mixtures. Yellow or orange for yellow crystal or crystalline powder; there are special smell, taste wei ku, cited wet. This product dissolved in water, ethanol, in a minimal solution in acetone, insoluble in ether.

 

It belongs to vitaminanalogues. It could be used to improve resistance of capillary. Vessel. For nosebleed, retinal hemorrhage, gingival and alveolar hemorrhage, gastrointestinal bleeding, bleeding hemorrhoids, as well as pre-operative or post-operative bleeding prevention and treatment.

 

Assay: Methyl Hesperidin 94% by UV

Appearance: Yellow Powder

Particle Size: 100% through 80 Mesh

Loss on Drying: < 5.0%

Heavy Metals: < 20ppm

Arsenic(As): < 2ppm

Lead(Pb): < 2ppm

 

Total Plate Count: < 10,000cfu/G

Yeast & Mold: < 1,000cfu/G

E.Coli.: Negative

Salmonella: Negative

 

 

11. Hesperidin Methyl Chalcone

Hesperidin methyl chalcone is obtained by chemical synthesis from Hesperidin (extracted from immature citrus fruit). Hesperidin methyl is methylated derivative of the flavonoid hesperidin. Due to different control in chemical reaction, two styles of hesperidin methyl are obtained: Chalone style and Dihydro-Flavone style.

 

Hesperidin methyl chalcone supports and protects the integrity of the vascular system with particular activity in the capillaries and veins. Hesperidin methyl chalcone has been shown to help strengthen capillaries by increasing capillary resistance and decreasing capillary permeability. Increased venous motility, tone, and the ability of vessels to dilate are also enhanced by hesperidin methyl chalcone.

 

Assay: Hesperidin Methyl Chalcone 98% by UV

Appearance: Yellow Powder

Particle Size: 100% through 80 Mesh

Loss on Drying: < 5.0%

Heavy Metals: < 20ppm

Arsenic(As): < 2ppm

Lead(Pb): < 2ppm

 

Total Plate Count: < 10,000cfu/G

Yeast & Mold: < 1,000cfu/G

E.Coli.: Negative

Salmonella: Negative

 

 

12. Naringin Dihydrochalcone

As a new-style sweetening agent, naringin dihydrochalcone(naringin DC) is 500-700 times sweeter than sucrose. Due to its many advantages like high sweet taste, low caloric, innocuity and safety, it can be used in edible, medicine and commodity trade. And because it tastes cleanlily, has long aftertaste and special faint scent and owns fine virtue of shielding bitterness, Naringin DC is in particular used for milky goods, fattiness and grease, freezed foodstuff, machining vegetable, jelly, comfiture, nonalcohol beverage, chewing gum, toothpaste and troche. Besides, it can substitute sugar for decreasing body absorption to sugar. It is really a evangel for fat person and patients who can not eat sugar.

 

Assay: Naringin Dihydrochalcone 98% by HPLC

Appearance: White Powder

Particle Size: 100% through 80 Mesh

Loss on Drying: < 5.0%

Heavy Metals: < 20ppm

Arsenic(As): < 2ppm

Lead(Pb): < 2ppm

 

Total Plate Count: < 10,000cfu/G

Yeast & Mold: < 1,000cfu/G

E.Coli.: Negative

Salmonella: Negative